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TopWeightLoss.us
Last Updated: October 2026

Best GLP-1 Weight Loss Providers of 2026

Compounded semaglutide starts at $49/mo and tirzepatide at $89/mo. Every price below was checked on the provider's own site.

Licensed CliniciansHighly Rated PicksQuick Online Intake
Francheska Capistrano, Medical Content Reviewer

Francheska Capistrano, RMT, MPH

Clinically checked · Our review process

Our Most Popular
1
embody logo

Exceptional

9.8out of 10

Semaglutide from $69/mo, delivered in 1-2 days

Refund if not approvedFree expedited shipping

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Online doctor review and prescription · Dose changes through the patient portal

Starting price

$79$69/month

*Compounded medications are not FDA-approved.

  • Semaglutide $69/mo; tirzepatide $119/mo
  • 5-minute questionnaire; doctor review usually within 24 hours
  • Free 1-2 day shipping: cold-packed, tracked and insured
  • No insurance, no clinic visits, cancel anytime

from $69/month

Visit SiteRead full review
3.8Trustpilot(9,604)

embody is a low-cost, fully online way to get doctor-prescribed GLP-1 treatment: compounded semaglutide costs $69/month and compounded tirzepatide $119/month, with no insurance, hidden fees or clinic visits involved. You start with a health questionnaire that takes about 5 minutes. A medical practitioner then reviews your chart, which embody says usually happens within 24 hours and often in under 5. Approved orders ship in 1-2 days in tracked, insured, temperature-controlled packaging. embody is LegitScript-certified and fills prescriptions through US-based 503A compounding pharmacies. On Trustpilot, embody averages 3.8 from 9,604 reviews, a mixed-to-positive record. Recent reviews keep returning to two points. The first is proactive customer service: one tirzepatide patient writes, 'from my very first inquiry I've had excellent communication... customer service updated me every step.' The second is predictable pricing: 'Love the fact that there are no surprises as in costly up front cost.' An average of 3.8 also means some customers had bad experiences, so read both the positive and negative reviews before you decide, as you would with any provider.

Read full embody review
2
altRx logo

Exceptional

9.7out of 10

Low-cost GLP-1 care: semaglutide from $89/mo

Clear, flat pricingNo insurance needed

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Brand-name Ozempic, Zepbound and Wegovy · Once-weekly injection schedule

Starting price

$199$89/month

*Compounded medications are not FDA-approved.

  • Semaglutide from $89/mo; tirzepatide from $149/mo
  • Brand-name Ozempic, Zepbound and Wegovy available
  • Reviewed by a physician, PA or nurse practitioner
  • Free shipping, arriving in about 5-7 days

from $89/month

altRx is one of the cheapest ways to start GLP-1 treatment online: compounded semaglutide (GLP-1) costs from $89/month and compounded tirzepatide (GLP-1 + GIP) from $149/month, and neither price rises as your dose goes up. The company markets itself as "the #1 most affordable GLP-1 program," and its published price list mostly supports the claim. altRx also keeps a real brand-name shelf, which few rivals do: Ozempic at $1,149, Zepbound at $1,249 and Wegovy at $1,579 per month. How it works: you take a short online assessment, a licensed provider (a physician, PA or nurse practitioner) reviews it, and if treatment is appropriate the prescription goes to a licensed US pharmacy. Shipping is free and takes about 5-7 days. You do not need insurance, Buy Now, Pay Later is offered, and you can pause or cancel at any time. Two caveats before you decide. First, delivery is slower than at 1-2 day providers such as embody and DirectMeds. Second, altRx's Trustpilot profile does not currently show an overall score. The individual reviews we quote here are genuine, but there is no independent average to compare with Medvi (4.3 from 14,987 reviews) or embody (3.8 from 9,604). One of the 4-star reviews we found mentions a refill 'yet to be fulfilled with zero reason as to why', which is worth weighing against the low price.

Read full altRx review
3
Eden logo

Excellent

9.6out of 10

Flat-price GLP-1: semaglutide $99/mo, tirzepatide $129/mo at every dose

One price at every doseNo membership or long-term plan

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Doctor-guided dosing and ongoing clinical care · Human support available 24/7

Starting price

$99/month

*Compounded medications are not FDA-approved.

  • Semaglutide $99/month, the same at every dose
  • Tirzepatide $129/month, the same at every dose
  • All-inclusive price: no membership, annual or long-term plan
  • Doctor-guided care with 24/7 human support

from $99/month

Visit SiteRead full review
4.5Trustpilot(4,917)

Eden sells compounded GLP-1 medication at a price that does not move: $99/month for semaglutide and $129/month for tirzepatide, in month one and every month after, at every dose. Eden's pricing page sums it up as 'the price you start with is the price you keep'. There is no membership, no annual plan and no long-term commitment. Care is doctor-guided with 24/7 human support, and Eden says its medication is made in the US under strict quality oversight. Signing up starts with a free assessment of about three minutes, and insurance is not required. Eden holds a 4.5 average from 4,917 Trustpilot reviews on a profile it claimed in June 2024. The newest reviews read like a list of support staff: 'Ann was a great help', 'MELANIE was fantastic!!', 'Sandra was super helpful!', 'Joanne with customer support was great'. Every one of the latest reviews we captured names the person who helped. A reviewer who moved over after a previous provider raised prices wrote that Eden's 'high ratings for fair pricing, customer service, and support of the doctors was the deciding factor for me, and they were spot on.' One thing you should know: in June 2026 the FDA sent Eden a warning letter about compounded GLP-1 marketing claims on its website. It was one of 25 letters sent to telehealth companies that month, and altRx received the same type of letter in that batch. The letter concerns marketing language, not a finding about the medication or patient safety. We mention it so you have the full picture, and as a reminder that no compounded GLP-1 from any provider is FDA-approved.

Read full Eden review
4
welludr logo

Excellent

9.4out of 10

Compounded semaglutide from $49/month and tirzepatide from $89/month

1,000,000+ patientsWeight-loss warranty

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Brand-name Ozempic and Zepbound · Online provider review and prescription

Starting price

$49/month

*Compounded medications are not FDA-approved.

  • Semaglutide from $49/mo; tirzepatide from $89/mo
  • Same price at every dose; ships every 4 weeks
  • Brand-name Ozempic and Zepbound also offered
  • Board-certified specialists plus a Medical Weight-Care Coach

from $49/month

Visit SiteRead full review
4.6Trustpilot(2,188)

welludr has the lowest compounded GLP-1 prices in our ranking: semaglutide from $49/month and tirzepatide (GLP-1/GIP) from $89/month. Both ship every 4 weeks and cost the same at any dose. For patients who want brand-name medication, welludr also offers Ozempic and Zepbound. The company says more than 1,000,000 patients have used its GLP-1 medications. Treatment is fully online with no office visit. Board-certified specialists set your plan, a Medical Weight-Care Coach supports you throughout, and the program is backed by a weight-loss warranty. A standing offer lets you lock in $200 off every month, or $49/month for life on a 12-month plan. welludr averages 4.6 from 2,188 Trustpilot reviews, and the recent ones read like a record of helpful support. 'I filled out the intake and within 4 days had been approved and meds shipped and received,' one reviewer writes. Another says the team rebuilt her plan at a lower price when money got tight, with 'no pressure to accept it.' Two caveats: standard delivery takes 3-5 business days, slower than the 1-2 days at embody or DirectMeds, and the $49/month headline rate requires a 12-month plan.

Read full welludr review
5
ro logo

Excellent

9.3out of 10

Online weight loss care from an established telehealth brand

Treatments offered

Compounded semaglutide · Brand-name GLP-1 medication · Metabolic support supplements · Dose changes guided by your provider

  • Consultations with board-certified providers
  • Several GLP-1 medication options
  • In-house pharmacy with home delivery
  • Ongoing care and dose adjustments
Visit SiteRead full review
3.9Trustpilot(7,105)

ro gives you a simple, fully online path to prescription weight loss care. You consult a licensed provider from home, receive a GLP-1 prescription if appropriate, and get ongoing follow-ups and dose adjustments, with medication delivered through ro's integrated pharmacy. The weight loss program builds on the reputation ro has earned as one of the more established names in telehealth.

Read full ro review
6
TrimRx logo

Excellent

9.1out of 10

Custom-dosed GLP-1 plans with ongoing provider check-ins

HIPAA compliantMade in the USA

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Dosing schedule customized by your provider · Unlimited check-ins for the length of treatment

Starting price

$289$149/month

*Compounded medications are not FDA-approved.

  • Semaglutide $149/month at every dose
  • Tirzepatide $259/month
  • Custom dosing plus unlimited provider check-ins
  • Free consultation and tracked delivery, often next-day

from $149/month

Visit SiteRead full review
3.8Trustpilot(5,392)

TrimRx (sometimes written TrimRx) charges $149/month for compounded semaglutide and $259/month for compounded tirzepatide, and its selling point is custom dosing rather than the lowest price. The semaglutide rate includes a $140 discount and stays the same at every dose, and both plans bundle the consultation, tracked delivery and unlimited check-ins with your provider. Getting started is the standard cash-pay process: a free 2-minute assessment, a review by a qualified doctor (plus a telehealth call if they need more information), then free tracked shipping that often arrives the next day. TrimRx's Trustpilot average is 3.8 from 5,392 reviews, which is a mixed record. The best reviews are striking. One tirzepatide patient writes, 'I have lost 41 lbs... My high blood pressure is gone,' and another describes a rep as 'very kind and helpful' even though that reviewer decided to go with their own doctor. Still, a 3.8 means a real share of customers had problems, and it ties for the lowest published average among the affiliate providers we rank. Read both positive and negative recent reviews before you sign up, and compare the price with the $49-$89 entry plans at welludr, embody and altRx.

Read full TrimRx review
7
SHED logo

Very Good

8.9out of 10

20% off your first month of GLP-1 treatment

Lose 5% in 120 days or money backFully online visit and checkout

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Health coaching on every plan · Progress tracking and regular check-ins

Starting price

$199/month

*Compounded medications are not FDA-approved.

  • Semaglutide from $199/mo; tirzepatide from $299/mo
  • First month 20% off
  • Health coaching included with every plan
  • Money back if you do not lose 5% of body weight in 120 days

from $199/month

Visit SiteRead full review
4.6Trustpilot(1,134)

SHED is the GLP-1 program to look at if you want coaching built in. Every plan includes health coaching alongside compounded semaglutide (from $199/month) or compounded tirzepatide (from $299/month), and the first month is 20% off. More than 150,000 members use the service. The process runs entirely online: you complete a visit, and if a provider approves you, the medication ships directly to your home. Plans are HSA/FSA approved. SHED also offers the most specific guarantee in our ranking: if you do not lose 5% of your body weight in 120 days, you get your money back. SHED averages 4.6 from 1,134 Trustpilot reviews, and recent reviews focus on the people behind the program. One member said of her onboarding call, 'she was amazing, VERY informative... made me feel very comfortable on my journey', which fits the coaching-led pitch. The trade-off is cost. At $199-$299/month, SHED has the highest compounded prices among our affiliate providers, so you are paying for coaching and the guarantee as well as the medication.

Read full SHED review
8
Medvi logo

Very Good

8.7out of 10

Prescription weight loss without the hassle

HSA/FSA approvedNo membership or hidden fees

Treatments offered

Weekly semaglutide (GLP-1) injections · Weekly tirzepatide (GLP-1/GIP) injections · Daily oral dissolving GLP-1 tablets, no needles · Video visits, free dietitian access and care coaching

Starting price

$199$99/month

  • Semaglutide (GLP-1) injections from $99/month (normally $199)
  • Tirzepatide (GLP-1/GIP) injections from $166/month (normally $299)
  • Needle-free daily dissolving GLP-1 tablets at $249/month
  • Video visits, free dietitian access and care coaching

from $99/month

Visit SiteRead full review
4.3Trustpilot(14,987)

Medvi is an all-inclusive GLP-1 program with one of the two largest verified review records in our ranking: 4.3 from 14,987 Trustpilot reviews, a volume few telehealth weight loss brands come close to. Everything is billed as one flat price, and a current promotion cuts it roughly in half. Weekly semaglutide (GLP-1) injections start at $99/month (normally $199), and weekly tirzepatide (GLP-1/GIP) injections start at $166/month (normally $299). For patients who would rather avoid needles, daily oral dissolving tablets cost $249/month. There is no membership fee and there are no hidden charges, shipping is free, and dietitian access and care coaching are included at no extra cost. Plans are HSA/FSA approved. Care is hands-on. Recent Trustpilot reviews describe video visits that start on time ('Video visit was made very easy and reminders were sent right before my visit'), providers who 'took her time, answered any questions,' and follow-up through secure messaging. At $99, Medvi's bundle now competes with the budget tier. The one caveat is that promotions end, and the standard prices are $199 and $299.

Read full Medvi review
9
Sprout logo

Very Good

8.5out of 10

$200 off your first month of GLP-1 care

$200 off month oneShips within 2 days

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Brand-name Wegovy (semaglutide) pen · Personalized treatment plans guided by a provider

Starting price

$149/month

*Compounded medications are not FDA-approved.

  • Semaglutide from $149/mo
  • Tirzepatide from $199/mo
  • Brand-name Wegovy from $1,799/mo
  • Prescriptions ship within 2 days

from $149/month

Visit SiteRead full review
4.1Trustpilot(188)

Sprout is a mid-priced GLP-1 telehealth program that competes on speed and personalization: prescriptions ship within 2 days of approval, and each treatment plan is built around your health goals. The menu covers compounded and brand-name medication. Compounded semaglutide starts at $149/month and compounded tirzepatide at $199/month, while brand-name Wegovy is available from $1,799/month for anyone who wants the branded pen. A standing offer takes $200 off the first month. Sprout averages 4.1 from 188 Trustpilot reviews. That is a small sample compared with Medvi or embody, but it is real. Recent reviews regularly praise the support team: one customer was 'immediately answered by a LIVE CS rep. No bots,' and several others name individual reps who solved their issues quickly. The negative reviews mention missing tracking notifications, a charge with no shipment after a skipped monthly check-in, sparse injection instructions and one report of hair loss on compounded tirzepatide. On price, Sprout sits in the middle: above the $49-$99 value tier and below TrimRx and SHED.

Read full Sprout review
10
Wellorithm logo

Very Good

8.4out of 10

Get started today for $147

Treatments offered

Compounded semaglutide · Compounded tirzepatide · Dosing optimized by algorithm · Treatment changes informed by your data

  • Treatment matching driven by algorithms
  • Licensed provider consultations included
  • Personalized GLP-1 medication plans
  • Progress tracking based on your data

Wellorithm leans on technology. Its proprietary algorithms analyze patient data to suggest a personalized GLP-1 treatment plan, and licensed providers review and oversee that plan. The result is a quick, data-led process that still keeps a clinician in charge of your care.

Read full Wellorithm review
11
DirectMeds logo

Very Good

8.2out of 10

GLP-1 plans from $147

One price at every doseNo hidden fees or membership

Treatments offered

Compounded semaglutide · Compounded tirzepatide · Dose optimization guided by a provider · Ongoing monitoring during treatment

Starting price

$147/month

*Compounded medications are not FDA-approved.

  • Doctor-prescribed GLP-1 from $147/month
  • Weekly injections or needle-free sublingual drops
  • Compounded semaglutide and tirzepatide
  • Fully online, with telemedicine visit and prescription included

from $147/month

Visit SiteRead full review
4.6Trustpilot(16,390)

DirectMeds is a pharmacy-direct telehealth service that charges one flat price, starting at $147/month, for doctor-prescribed GLP-1 treatment. More than 250,000 customers have used it. You can choose compounded semaglutide or tirzepatide as a weekly injection, or as sublingual oral drops if you prefer to avoid needles, and the drops cost the same. The telemedicine visit and prescription are included, the process is fully online, and you do not need insurance. There are no hidden fees and no monthly membership. Shipping is free and arrives in 1-2 days, and you can cancel at any time. DirectMeds averages 4.6 from 16,390 Trustpilot reviews, making it one of only two providers in our ranking with a five-figure review count. Recent reviews keep crediting a support team you can actually reach, with one reviewer praising 'a great personnel... answering the phone and following up' and others naming the reps who fixed their orders. The service is deliberately lean: no coaching program and no brand-name medication, just the visit, the medication and fast delivery at one flat price.

Read full DirectMeds review
12
HealthRx logo

Very Good

8.0out of 10

GLP-1 from $99/mo: clinician review to overnight delivery

LegitScript certifiedLicensed 503A pharmacies

Treatments offered

Compounded semaglutide (once-weekly GLP-1 injection) · Compounded tirzepatide (once-weekly GLP-1 + GIP injection)

Starting price

$99/mo12-month prepaid plan, $1,188 due at checkout

*Compounded medications are not FDA-approved.

  • Semaglutide $99/month on a 12-month prepaid plan
  • Tirzepatide plans from $179/month
  • Independent US-licensed clinician reviews each request
  • Free overnight cold-chain shipping with lot tracking

from $99/mo12-month prepaid plan, $1,188 due at checkout

HealthRx bundles its GLP-1 program into a single price that covers everything. Semaglutide costs $99/month on a 12-month prepaid plan ($1,188 paid at checkout), and tirzepatide plans start at $179/month. An independent US-licensed clinician reviews every request, so approval is never automatic. A licensed 503A pharmacy then prepares the medication and ships it overnight, free, in temperature-controlled, lot-tracked packaging. Below we cover what the price includes and which patients the prepaid model suits.

Read full HealthRx review
13
bmiMD logo

Good

7.9out of 10

Compounded GLP-1 care prescribed online and shipped cold-chain

Treatments offered

Compounded semaglutide injection (GLP-1) · Compounded tirzepatide injection (GLP-1 + GIP) · Microdose versions of semaglutide and tirzepatide · Other weight-related options, such as metformin and MIC + B12

  • Compounded semaglutide and tirzepatide, with microdose versions
  • Licensed provider prescribes online; ships to about 49 states
  • Medication arrives cold-chain at your door
  • Trustpilot: 4.4 average from 870 reviews
Visit SiteRead full review
4.4Trustpilot(870)

bmiMD prescribes compounded GLP-1 medication online and ships it cold-packed to patients in most US states. The New York-based telehealth company offers semaglutide and tirzepatide, including microdose versions of both, and holds a 4.4 average across 870 Trustpilot reviews. Two themes come up again and again in those reviews: customer service that actually responds, and deliveries that arrive properly chilled. One recent reviewer wrote, "Medication works as it should. Always delivered on time and packaged properly with cold packs." Another reported going "from 238 to 213 in 3 weeks." Sign-up follows the familiar cash-pay route: you fill in an online medical intake, a licensed provider reviews it, and bmiMD refunds you if you are not approved. Two points to know up front: bmiMD shows plan pricing at checkout rather than advertising a single headline rate, so check the current cost on its site, and support is handled by message rather than by phone.

Read full bmiMD review

Best GLP-1 Weight Loss Programs Online, Compared

The best online weight loss program is the one whose price, prescriber support and plan terms fit your situation; the medication is only one part of the choice. Top Weight Loss compares GLP-1 providers on monthly cost, clinical support, treatment plans, eligibility rules and long-term value, because these differ widely from one provider to the next. For a quick starting point, our provider matching quiz recommends a program based on your answers.

Each program in our ranking is assessed on medication access, affordability, prescriber support, customer experience and overall value. Our full provider reviews cover each program in detail, and head-to-heads such as altRx vs embody show two programs side by side. Want the evidence without scores? The GLP-1 provider comparison lines up eight providers on verified prices, Trustpilot patterns, Reddit experiences and cancellation terms, and the GLP-1 price index keeps every verified price together with a public record of each change.

The aim is simple: help you find the provider that matches your health goals, your budget and the way you want to be treated.


How Much Do Online GLP-1 Weight Loss Programs Cost in 2026?

Monthly prices in our ranking start at $49 for semaglutide and $89 for tirzepatide, both at welludr on its 12-month plan. Each figure below is the price published on the provider's own site, not an estimate. Most plans bundle the prescription, clinician consultations, ongoing support and home delivery into a single monthly fee.

ProviderSemaglutideTirzepatidePricing model
welludr$49/mo$89/moBest rate requires a 12-month plan
embody$69/mo$119/moFlat monthly price, no commitment
altRx$89/mo$149/moSame price at every dose, buy now pay later
Medvi$99/mo promo (reg. $199)$166/mo promo (reg. $299)All-inclusive, with a dietitian
HealthRx$99/mofrom $179/moPrepaid for 12 months
DirectMeds$147/mo$147/moFlat price, needle-free option
Sprout$149/mo$199/moBrand-name Wegovy also available
TrimRx$149/mo at every dose$259/moNo contract
SHED$199/mo$299/moResults guarantee with money back

Prices as published and verified on October 16, 2026. Check current pricing on each provider's site before you sign up. For yearly totals and a closer look at the budget options, see the cheapest verified GLP-1 comparison.


How Do You Choose a GLP-1 Telehealth Provider?

Start with the one thing every legitimate online weight loss clinic has in common: a licensed clinician reviews your health intake before anything is prescribed. After that, five checks set the strongest telehealth weight loss providers apart:

  • An all-inclusive price, published up front:a real monthly figure on the site, not a "from" price that climbs at checkout
  • Genuine prescriber review: a licensed clinician, and a provider prepared to turn down treatment when it is not appropriate
  • Clear pharmacy sourcing: US-licensed 503A compounding pharmacies that are named or can be verified
  • Support you can reach: help with dose changes and side effects, and a real person to contact
  • Shipping suited to the medication: tracked, insured and kept cold where required

Our full ranking methodology shows how each check is scored. Short on time? The 60-second matching quiz factors in your budget and priorities, and our step-by-step guide to choosing a telehealth weight loss provider walks through the whole decision.

What Should You Know Before Starting a GLP-1?

GLP-1 medications need a prescription from a licensed clinician, and they are not right for everyone. Side effects can occur, most often during the first few weeks while the body adjusts.

These medications generally work best alongside everyday habits such as balanced eating and regular physical activity.

For both safety and lasting results, choose a provider that screens you properly before prescribing and follows up with you throughout treatment.

A woman getting a GLP-1 weight loss injection ready

What Should You Weigh Before Picking a Program?

Six factors deserve a look before you commit to any weight loss provider. Our guide to your first month on weight loss medication explains what to expect once you start:

  • Which medications are offered
  • Who qualifies medically
  • Possible side effects
  • How much support the provider gives
  • How flexible the plan is
  • The total cost of treatment

Side-by-side comparisons such as altRx vs ro, altRx vs TrimRx and embody vs ro make the differences easier to see before you decide.


Which GLP-1 Medications Do Online Programs Prescribe?

Most online weight loss programs prescribe GLP-1 receptor agonists. The common options are listed below, and our explainer on how GLP-1 medications work covers the mechanism in detail:

  • Semaglutide
  • Tirzepatide
  • Liraglutide

Which medication you can get depends on where you live, your medical history and the provider's own policies. Would you rather avoid injections? Read our guide to weight loss pills.

Shop GLP-1 plans by product

Every provider's published plans side by side - cheapest first, with the conditions under each price.


GLP-1 Weight Loss Medications by the Numbers (2026)

Published clinical trial data shows that GLP-1 medications are the most effective prescription weight loss treatments available today. The table sums up the headline results from the major trials.

MedicationAverage Weight LossTrial Length
Semaglutide (Wegovy)~15% of body weight68 weeks (STEP trials)
Tirzepatide (Zepbound)Up to 20.9% average (22.5% on treatment)72 weeks (SURMOUNT trials)
Liraglutide (Saxenda)~5-8% of body weight56 weeks

Sources: published results of the STEP (semaglutide), SURMOUNT (tirzepatide) and SCALE (liraglutide) clinical trials. Individual results vary. Compounded prices reflect typical telehealth provider rates as of October 2026.

Tirzepatide vs Semaglutide: How Do They Differ?

Tirzepatide produced greater average weight loss than semaglutide in clinical trials, and the two are the most effective GLP-1 medications for weight loss. Both are weekly injections that work in similar ways, but they differ in trial results, approvals and insurance coverage. Compare tirzepatide providers and semaglutide providers to find the one that suits your goals.

FactorTirzepatideSemaglutide
Average weight loss in trialsAbout 15.0%-20.9% average loss at 72 weeks (SURMOUNT)About 14.9% mean loss at 68 weeks (STEP)
FDA approvalFDA-approved for chronic weight management as Zepbound® and for type 2 diabetes as Mounjaro®FDA-approved for chronic weight management as Wegovy® and for type 2 diabetes as Ozempic®
DosingOnce-weekly injectionOnce-weekly injection
Best suited toPeople aiming for the larger average weight loss seen in clinical trials, when clinically appropriatePeople who want an FDA-approved GLP-1 backed by extensive long-term safety and outcomes data
Insurance coverageNot always covered by insurance yetVaries by insurer; may be listed on more formularies

Wegovy vs Ozempic: What Is the Difference?

Wegovy and Ozempic contain the same drug, semaglutide; they differ in dose and approved use. Wegovy is made for weight management, while Ozempic was developed for type 2 diabetes and is often prescribed off-label for weight loss. Our Wegovy providers and Ozempic for weight loss guides cover each one in more depth.

FactorWegovyOzempic
Average weight loss in trialsAbout 14.9% mean weight loss at 68 weeks in obesity trials (STEP-1)5-10% weight loss seen in type 2 diabetes trials, depending on dose
FDA approvalYes, FDA-approved specifically for weight managementFDA-approved for type 2 diabetes; use for weight loss is off-label
DosingOnce-weekly injectionOnce-weekly injection
Best suited toPeople who want an FDA-approved medication for long-term weight managementPeople with diabetes who may also benefit from losing weight
Insurance coverageVaries, and coverage for obesity medications is often limitedCoverage may be broader when prescribed for diabetes

Sources: STEP-1 (semaglutide) and SURMOUNT (tirzepatide) clinical trial data. Zepbound®, Mounjaro®, Wegovy® and Ozempic® are trademarks of their respective manufacturers. Individual results vary, and each of these medications requires a prescription from a licensed clinician.

How Much Does GLP-1 Weight Loss Medication Cost?

Without insurance, brand-name GLP-1 medications cost $900-$1,400 a month at retail. Licensed telehealth providers offer compounded semaglutide and tirzepatide for much less, typically $49-$299 a month with physician consultations, medication and home delivery included. Our GLP-1 cost guide breaks the numbers down.

How Long Does GLP-1 Medication Take to Work?

Most people notice a smaller appetite within the first 1-2 weeks on a GLP-1 medication. Visible weight loss usually starts around weeks 4-8, and clinical trials recorded peak weight loss at 68-72 weeks of treatment. See our semaglutide timeline guide for more detail.

Can You Get GLP-1 Medication Online?

Yes. Licensed telehealth providers can prescribe GLP-1 medications after a fully online medical evaluation, and it typically takes 1-5 days from sign-up to delivery. Every provider featured on Top Weight Loss uses licensed physicians to prescribe and includes ongoing medical oversight. Our guide to getting GLP-1 medication online explains each step.


How Did We Evaluate These Providers?

Each provider's place in the ranking reflects six factors:

  • How transparent the pricing is
  • Which medications are available
  • The level of clinical oversight
  • Customer experience
  • Plan flexibility
  • Overall value

Recommendations are reviewed and updated on an ongoing basis so you can compare weight loss providers with confidence. For more research, browse all of our weight loss guides and articles.

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